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ea0081p283 | Adrenal and Cardiovascular Endocrinology | ECE2022

A single dose of Neutrophil Elastase inhibitor Elafin does not alter CBG cleavage during post-surgical stress in humans in vivo

Boyle Luke D , Nixon Mark , Underhill Caroline , Hill Lesley A , Lewis John G , Hammond Geoffrey L , Wiedow Oliver , Henriksen Peter A , Stimson Roland H , Walker Brian R

Introduction: Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and modulates free cortisol levels. Observations in vitro show that CBG is cleaved by neutrophil elastase (NE), a mechanism proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. However, detection of cleaved CBG in vivo in human plasma is controversial, and any influence of NE on CBG cleavage has not been tested in vivo...

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A single dose of Neutrophil Elastase inhibitor Elafin does not alter CBG cleavage during post-surgical stress in humans in vivo

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